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. Author manuscript; available in PMC: 2024 Oct 4.
Published in final edited form as: J Neurochem. 2024 Feb 5;168(9):1923–1936. doi: 10.1111/jnc.16067

Figure 3. 4m-Tg2652 mice exhibit stable PNNs in the presence of pTau accumulation without gliosis.

Figure 3.

5-region stereology analysis (Bregma −1.4 to −1.8 mm) of 4-month-old Tg2652 mice exhibit robust accumulation of A) pTau (AT8) without B) gliosis (GFAP, astrogliosis) in association with increased C) WFA+ PNNs (PNN CS-GAGs) and D) ACAN (PNN CSPG). Scale bar: 0.5 mm, representative images from male mice, dapi included in all images. Statistics reported in Supplemental Table 4.