Fig. 6.

Increased Treg recruitment promotes constructive remodeling of the dECM material in vivo. (A–J) Representative HE-stained images of the dECM material from the control and CD28-SA groups. Purple arrows indicate inflammatory cells at the edge of the dECM material. Neutrophils are indicated by yellow arrows, capillaries by blue arrows, fibroblasts by green arrows, monocytes by red arrows, and fibrous connective tissue by black arrows. The gradual replacement of fibroblasts (green arrows) by fibrocytes (dark blue arrows) in the CD28-SA group is shown. (K) Statistical graph of the histological quantitative scores for the inflammation and tissue remodeling responses, with the higher scores in the CD28-SA group implying an improved constructive remodeling response. (L) Representative Masson and EVG images of the dECM material. (M, N) Statistical plot for the percentage of collagen fiber area in Masson images (M) and the elastic fiber percentage area in EVG images (N). ns = not significant, **p ≤ 0.01. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)