Figure 5.

No MPs were detected in brains after 10 weeks of MP treatment, but altered brain gene expression was observed

A: Adult flies were exposed to standard food or MP mixed in food at two doses. Treatment continued for 10 weeks, and sub-groups of flies were dissected and imaged at the end of weeks 2, 4, 6, 8, and 10. No MPs were observed in fly brains at any time point (scale bars=100 μm). B: MP exposure led to differential gene expression in fly brains. C: Gene Ontology (GO) enrichment analysis showed brain pathways altered by MP exposure (rich factor indicates degree of pathway enrichment score. Q-value represents significance of enriched pathway).