TABLE 1.
Expt | Virus(es) | n | Vol (μl) | PFU/ml (108) | Survival (h) |
---|---|---|---|---|---|
Single unilateral intravitreal injection | PRV-Bartha | 7 | 2 | 28 | 97–10 |
PRV-D | 2 | 2 | 3.2 | 48 | |
4 | 2 | 3.2 | 71–77 | ||
2 | 2 | 3.2 | 90 | ||
PRV-BaBlu | 1 | 2 | 4.75 | 48 | |
4 | 2 | 4.75 | 73 | ||
7 | 2 | 4.75 | 94–99 | ||
5 | 2 | 4.75 | 118–120 | ||
3 | 2 | 4.75 | 140 | ||
Simultaneous unilateral intravitreal injection | PRV-D, PRV-BaBlu | 2 | 2 each | 3.2, 4.75 | 60 |
4 | 2 each | 3.2, 4.75 | 72 | ||
1 | 2 each | 3.2, 4.75 | 85 | ||
3 | 2 each | 3.2, 4.75 | 96 (died) | ||
Simultaneous injection into different eyes | PRV-D, PRV-BaBlu | 2 | 2 each | 3.2, 4.75 | 77 |
2 | 2 each | 3.2, 4.75 | 85 | ||
Single injection into ventral stomach | PRV-BaBlu | 1 | 4 | 4.75 | 48 |
2 | 4 | 4.75 | 73 | ||
3 | 4 | 4.75 | 99 | ||
PRV-D | 3 | 4 | 3.2 | 70–72 | |
PRV-BaBlu followed 24 h later by PRV-D into ventral stomach | PRV-D, PRV-BaBlu | 1 | 2 each | 3.2, 4.75 | 72 |
1 | 2 each | 3.2, 4.75 | 80 | ||
4 | 2 each | 3.2, 4.75 | 94 | ||
PRV-D followed 24 h later by PRV-BaBlu into ventral stomach | PRV-D, PRV-BaBlu | 1 | 2 each | 3.2, 4.75 | 65 |
2 | 2 each | 3.2, 4.75 | 73 |