Table 1.

CHIKV vaccine clinical trials are registered on the following websites: https://www.clinicaltrials.gov and https://www.anzctr.org.au.

Vaccine candidate	Clinical trial status	Intervention (Biological – B, Drug – D)	Sponsored by	Collaborator	Clinical trial registration no.	Study Status	Sex	Age	Phase	Enrollment	Study design Allocation: na intervention model	Study type	References
Pxvx0317	Completed	Biological – Chikv Vlp, Adjuvanted	Bavarian Nordic	Emergent Biosolutions	Nct05065983	Completed	All	Adult	2	25	Single – Group Masking – None (Primary Purpose – Prevention)	Interventional	https://clinicaltrials.gov/study/NCT05065983?intr=Nct05065983&rank=1
Pxvx031	Recruiting	Biological – Pxvx0317 Vaccine Booster & Placebo Booster	Bavarian Nordic		Nct06007183	Recruiting	All	Child, Adult, Older Adult	3	800	Parallel – Masking: Triple (Participant, Care Provider, Investigator) (Primary Purpose – Prevention)	Interventional	https://clinicaltrials.gov/study/NCT06007183?intr=PXVX0317%20vaccine%20booster&rank=1
Live-Attenuated Chikungunya Virus Vaccine	Completed	Biological – Vla1553 & Placebo	Valneva Austria Gmbh		Nct04546724	Completed	All	Adult, Older Adult	3 3	4,128	Parallel – Masking: Double (Participant, Investigator) (Primary Purpose – Prevention)	Interventional	https://clinicaltrials.gov/study/NCT04546724?intr=Nct04546724&rank=1
Vla1553	Not Yet Recruiting	Biological – Vla1553	Valneva Austria		Nct06028841	Not Yet Recruiting	All	Adult, Older Adult	3	75	Single – Group Masking – None (Primary Purpose – Prevention)	Interventional	https://clinicaltrials.gov/study/NCT06028841?intr=Nct06028841&rank=1
Chikungunya Vaccine	Active Not Recruiting	Drug – Bbv87 Chikungunya Vaccine & Normal Saline	International Vaccine Institute		Nct04566484	Active Not Recruiting	All	Child, Adult, Older Adult	2	3,210	Sequential – Masking Double (Participant, Investigator) (Primary Purpose – Prevention)	Interventional	https://clinicaltrials.gov/study/NCT04566484?intr=Nct04566484&rank=1
Live-Attenuated Chikungunya Virus Vaccine	Completed	Biological – Biological Vaccine Vla1553	Valneva Austria Gmbh		Nct04786444	Completed	All	Adult	3	409	Parallel – Masking: Double (Participant, Investigator) (Primary Purpose –Prevention)	Interventional	https://clinicaltrials.gov/study/NCT04786444?intr=Nct04786444&rank=1
Chikungunya And Zika Vaccines	Completed	Biological – Chik Low Dose, Chik Mid Dose, Chik High Dose & Zika Low Dose, Zika Mid Dose, Zika High Dose & Saline Placebo	University Of Oxford		Nct04440774	Completed	All	Adult	1 1	120	Sequential – Masking – Double (Participant, Care_Provider) (Primary Purpose – Prevention)	Interventional	https://clinicaltrials.gov/study/NCT04440774?intr=Nct04440774&rank=1
Vla1553	Not Yet Recruiting	Biological – Vla1553 Full Dose, Vla1553 Half Dose & Control	Valneva Austria Gmbh		Nct06106581	Not Yet Recruiting	All	Child	2	300	Parallel – Masking – Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) (Primary Purpose – Prevention)	Interventional	https://clinicaltrials.gov/study/NCT06106581?intr=Nct06106581&rank=1
Live-Attenuated Chikungunya Vaccine	Not Yet Recruiting	Biological – Active & Placebo	Butantan Institute	Valneva Austria Gmbh	Nct04650399	Active Not Recruiting		Child	3	750	Parallel – Masking: Double (Participant, Investigator), (Primary Purpose – Prevention)	Interventional	https://clinicaltrials.gov/study/NCT04650399?intr=Nct04650399&rank=1
Chikungunya Vaccine, Pxvx0317 Chikv-Vlp	Completed	Biological – Chikv Vlp / Unadjuvanted, Chikv Vlp /Adjuvanted & Placebo	Emergent Biosolutions	Bavarian Nordic	Nct03483961	Completed		Adult	2	445	Parallel – Masking – Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) (Primary Purpose – Prevention)	Interventional	https://clinicaltrials.gov/study/NCT03483961?intr=Nct03483961&rank=1
Vla1553	Not Yet Recruiting	Biological – Vla1553		Valneva Austria Gmbh	Nct04838444	Active Not Recruiting		Adult, Older Adult	3	363	Single – Group Masking – None (Primary Purpose – Prevention)	Interventional	https://clinicaltrials.gov/study/NCT04838444?intr=Nct04838444&rank=1