Table 5.
Rates of response and toxicities among CAR-T recipients based on dynamic GA-MDC recommendation
| Outcome | Dynamic GA-MDC recommendation |
All patients (N = 53) | P value | |
|---|---|---|---|---|
| Proceed (n = 47) | Decline (n = 6) | |||
| Response rate, n (%) | 21 (44.7) | 5 (83.3) | 26 (49.1) | .10 |
| LOS, median (range) | 17.0 (69.0) | 30.5 (48.0) | 17.0 (69.0) | .05 |
| Discharge to rehabilitation center, n (%) | 5 (10.6) | 4 (66.7) | 9 (17.0) | .01 |
| Readmission, n (%) | 15 (31.9) | 2 (33.3) | 28 (32.1) | 1.00 |
| ICU admission, n (%) | 3 (6.4) | 3 (50.0) | 6 (11.3) | .76 |
| ICANS rate, n (%) | ||||
| Any grade | 22 (46.8) | 3 (50.0) | 25 (47.2) | 1.00 |
| 0-1 | 33 (70.2) | 3 (50.0) | 36 (67.9) | .37 |
| 2+ | 14 (29.8) | 3 (50.0) | 17 (32.1) | |
| CRS rate, n (%) | ||||
| Any grade | 40 (85.1) | 5 (83.3) | 45 (84.9) | 1.00 |
| 0-1 | 32 (68.1) | 4 (66.7) | 36 (67.9) | 1.00 |
| 2+ | 15 (31.91) | 2 (33.3) | 17 (32.1) | |
Deferred or declined patients successfully completing optimization recommendations that constituted the initial barrier were reclassified as proceed for the dynamic GA-MDC recommendation. All others were classified as declined.