Table 3.
Significant metabolic pathways associated with PNS in the identified pediatric oncology literature.
| PNS | Significant metabolic pathways |
|---|---|
| Fatigue | Xenobiotics metabolisma10 |
| Microbial gut flora metabolisma10 | |
| Tryptophan metabolisma,c1,10 | |
| Drug metabolism (cytochrome P450)c1 | |
| Peptide metabolismb11 | |
| Amino acid metabolismb11 | |
| Nucleotide metabolismb11 | |
| Lipid metabolismb11 | |
| Carbohydrate metabolismb11 | |
| Pain | De novo fatty acid biosynthesisc1 |
| Fatty acid metabolismc1 | |
| Linoleate metabolismc1 | |
| Fatty acid activationc1 | |
| Omega-3 fatty acid metabolismc1 | |
| Bile acid biosynthesisc1 | |
| Glycerophospholipid metabolismc1 | |
| Anxiety | Glycerophospholipid metabolismc1 |
| Phosphatidylinositol phosphate metabolismc1 | |
| Sialic acid metabolismc1 | |
| Tryptophan metabolismc1 | |
| Depressive symptoms | Limonene and pinene degradationc1 |
| Phoshatidylinositol phosphate metabolismc1 | |
| PNS cluster | Tryptophan metabolismc1 |
| Carnitine shuttlec1 |
PNS, psychoneurological symptoms.
a
Metabolic pathway found in urine sample.
b
Metabolic pathway found in cerebrospinal fluid sample.
c
Metabolic pathway found in blood sample.