Table 4.

Factors associated with developing moderate/severe (univariate and multivariable logistic regression).

Variable	Univariable OR (95% CI)	p value	Multivariable OR∗ (95% CI)	p value
Age (year)
<12 years (toddlers and children)	Ref		Ref
≥12 and <18 years (adolescents)	4.85 (2.81-8.60)	<0.001	4.75 (1.84-13.70)	0.002
Sex
Girl	Ref		Ref
Boy	0.96 (0.57-1.61)	0.876	0.80 (0.32-1.99)	0.627
Latency (days)	1.02 (1.00-1.05)	0.042	1.01 (0.98-10.03)	0.669
Peak PT	1.09 (1.03-1.17)	0.009	1.25 (1.12-1.42)	<0.001
Peak INR	1.05 (0.97-1.19)	0.300	1.00 (0.87-1.11)	0.939
Peak albumin (g/L)	0.94 (0.90-0.98)	0.008	1.00 (0.91-1.09)	0.971
Peak creatinine (μmol/L)	1.01 (1.00-1.02)	0.020	1.00 (0.99-1.01)	0.799

INR, international normalized ratio; OR, odds ratio; PT, prothrombin time.

Values in bold denote statistical significance.

^∗Adjusted for age, sex, latency, peak PT, peak INR, peak albumin, and peak creatinine.