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. 2024 Aug 5;10(4):00909-2023. doi: 10.1183/23120541.00909-2023

TABLE 3.

Gene expression correlation matrix

ALOX15 CLC CYSLTR2 HRH4 SMPD3
Healthy controls
ALOX15 1 0.190 0.388* 0.556* 0.214
CLC 0.190 1 0.090 0.340* 0.245*
CYSLTR2 0.388* 0.090 1 0.438* 0.342*
HRH4 0.556* 0.340* 0.438* 1 0.091
SMPD3 0.214 0.245* 0.342* 0.091 1
Asthma
ALOX15 1 0.635* 0.755* 0.859* 0.423*
CLC 0.635* 1 0.602* 0.585* 0.199
CYSLTR2 0.755* 0.602* 1 0.748* 0.415*
HRH4 0.859* 0.585* 0.748* 1 0.355*
SMPD3 0.423* 0.199 0.415* 0.355* 1
Asthma+CRSwNP
ALOX15 1 −0.071 0.468* 0.491* 0.368*
CLC −0.071 1 0.339 0.611* 0.571*
CYSLTR2 0.468* 0.339 1 0.640* 0.633*
HRH4 0.491* 0.611* 0.640* 1 0.780*
SMPD3 0.368* 0.571* 0.633* 0.780* 1
N-ERD
ALOX15 1 0.209 0.459* 0.242 0.393
CLC 0.209 1 0.611* 0.717* 0.458*
CYSLTR2 0.459* 0.611* 1 0.663* 0.730*
HRH4 0.242 0.717* 0.663* 1 0.314
SMPD3 0.393 0.458* 0.730* 0.314 1

Data presented as Pearson's correlation coefficients. Bolding indicates statistically significant values higher than 0.7. Grey shaded boxes are repeated values in the bivariate matrix. CRSwNP: chronic rhinosinusitis with nasal polyposis; N-ERD: nonsteroidal anti-inflammatory drug-exacerbated respiratory disease. *: p<0.05.