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. Author manuscript; available in PMC: 2024 Aug 5.
Published in final edited form as: Mol Inform. 2023 Nov 14;43(1):e202300262. doi: 10.1002/minf.202300262

FIGURE 4.

FIGURE 4

Overview of protease cleavage assays. a–c) relative activity over triplicate experiments at a fixed compound concentration of 100 μM for Nsp5, Nsp3 and TMPRSS2, respectively. Red bars show compounds that reduce cleavage (relative) activity by more than 50%. Asterisks show highly fluorescent compounds that could not be analyzed. Not all compound labels are listed for clarity. d–f) dose-response curves at different compound concentrations. Solid lines in panel e–f show fits, panel d to guide the eye.