TABLE 3.
Baseline ICICLE‐PD clinical and cognitive variables (mean and standard deviation or N) by class.
| Measures |
Class 1: Cognitively intact N = 59 (28%) |
Class 2: Cognitively intact N = 83 (39%) |
Class 3: Steady decliners N = 57 (27%) |
Class 4: Rapid decliners N = 13 (6%) |
Significant differences * | ||||
|---|---|---|---|---|---|---|---|---|---|
| M/N | SD | M/N | SD | M/N | SD | M/N | SD | ||
| Clinical measures | |||||||||
| Age | 60.56 | 8.85 | 65.04 | 9.20 | 71.01 | 8.37 | 74.23 | 5.92 | 1,2 < 3,4; 1 < 2 |
| Education | 14.64 | 3.48 | 12.95 | 3.40 | 11.05 | 3.43 | 11.15 | 3.60 | 1 > 3,4; 2 > 3 |
| Sex | |||||||||
| Male | 33 | 53 | 41 | 8 | |||||
| Female | 26 | 30 | 16 | 5 | |||||
| Dx duration (month) | 5.36 | 4.91 | 5.17 | 5.00 | 6.36 | 5.62 | 4.34 | 2.79 | |
| MDS‐UPDRS‐III | 24.22 | 11.48 | 27.84 | 11.49 | 29.12 | 11.72 | 34.23 | 10.22 | 1 < 4 |
| H&Y | |||||||||
| 1 | 19 | 23 | 11 | 1 | |||||
| 2 | 35 | 46 | 34 | 7 | |||||
| 3 | 5 | 13 | 12 | 5 | |||||
| 4 | 0 | 1 | 0 | 0 | |||||
| MoCA | 28.43 | 1.29 | 26.12 | 1.86 | 22.53 | 2.35 | 17.91 | 2.39 | 2,3,4 < 1; 3,4 < 2 |
| LEDD | 129.03 | 95.98 | 187.30 | 177.41 | 195.50 | 154.52 | 210.77 | 119.75 | |
| GDS | 2.14 | 2.04 | 3.17 | 2.96 | 3.13 | 2.46 | 3.15 | 3.29 | |
| Cognitive measures | |||||||||
| CF | 25.05 | 6.04 | 22.10 | 5.39 | 17.16 | 5.81 | 16.38 | 8.10 | 3,4 < 1; 3 < 2 |
| PRM | 21.26 | 1.96 | 19.92 | 3.00 | 18.67 | 2.28 | 14.36 | 5.30 | 3,4 < 1; 4 < 3,2 |
| PAL a | 1.69 | 0.44 | 1.82 | 0.59 | 2.38 | 0.86 | 2.89 | 0.98 | 1,2 < 3,4 |
| SRM | 16.14 | 1.99 | 15.79 | 1.90 | 14.25 | 2.11 | 12.36 | 1.80 | 3,4 < 2,1 |
| OTS | 16.54 | 2.64 | 15.10 | 2.75 | 12.78 | 4.43 | 9.55 | 6.36 | 3,4 < 1 |
| Pentagon | 3,4 < 2,1 | ||||||||
| 0 | 0 | 2 | 0 | 2 | |||||
| 1 | 0 | 7 | 13 | 5 | |||||
| 2 | 59 | 74 | 44 | 6 | |||||
| SRT a | 329.90 | 96.08 | 371.84 | 165.61 | 366.24 | 69.43 | 415.12 | 80.74 | 1 < 4 |
| CRT a | 502.22 | 85.07 | 537.13 | 88.28 | 566.62 | 86.70 | 637.99 | 114.72 | 1 < 4 |
Abbreviations: CF, category fluency; CRT, Choice Reaction Time; Dx, disease; GDS, Geriatric Depression Scale; H&Y, Hoehn & Yahr; LEDD, Levodopa Equivalent Daily Dose; MDS‐UPDRS‐III, Movement Disorder Society Unified Parkinson's Disease Rating Scale III; MoCA, Montreal Cognitive Assessment; OTS, One Touch Stockings; PAL, Paired Associate Learning; PRM, Paired Recognition Memory; SRM, Spatial Recognition Memory; SRT, Simple Reaction Time.
a
Higher scores indicate poorer performance.
*
p < 0.001.