Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Apr 24;71(2):242–253. doi: 10.1165/rcmb.2023-0290OC

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 by the American Thoracic Society

This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0. For commercial usage and reprints, please e-mail Diane Gern.

PMC Copyright notice

Figure 1. — Dysregulated lipid metabolism of idiopathic pulmonary fibrosis (IPF) alveolar type II cells (AEC2s). (A) Activation scores of fatty acid biosynthesis (FAB), phosphatidylcholine biosynthesis (PCB), β-oxidation (BO), and surfactant homeostasis (SH) of AEC2s from healthy and IPF lungs (red, healthy; blue, IPF) analyzed from dataset GSE157996. (B and C) Violin plots of expression of lipid metabolism–related genes (B) and fatty acid β-oxidation, lipid droplet, and lipid uptake–related genes (C) in healthy and IPF AEC2s (red, healthy; blue, IPF). (D) Violin plots of expression of FASN and PLIN2 (perilipin 2) with published single-cell RNA sequencing (scRNA-seq) datasets. (E) IPA pathway analysis of human AEC2s from IPF versus healthy lungs analyzed with dataset GSE157996. PPARγ = peroxisome proliferator activated receptor γ. IPA = ingenuity pathway analysis.