Organon 84062 unpublished.

Methods	6‐week, double‐blind, randomised, single‐centre study, placebo wash‐out unclear
Participants	Psychiatric outpatients meeting DSM‐III criteria for a major depressive episode (single or recurrent), baseline 17‐item HAM‐D ≥ 18 Age: no data Sex: no data Exclusion criteria: not reported
Interventions	Amitriptyline: 15 participants Placebo: 15 participants Amitriptyline dose: no information provided
Outcomes	17‐item HAM‐D, MADRS, CGI, ZDS, PDI, drug account (primary outcome not defined)
Notes	We received the data from Organon 3‐arm, dose finding study comparing mirtazapine with amitriptyline and placebo Sponsor: Organon, The Netherlands
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomised, no further information
Allocation concealment (selection bias)	Unclear risk	Not explained
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Double‐blind, no further information
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Double‐blind, no further information
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information
Selective reporting (reporting bias)	Unclear risk	Insufficient information
Other bias	Unclear risk	Insufficient information