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. 2024 Jul 22;18:1395769. doi: 10.3389/fnins.2024.1395769

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Copyright © 2024 Maccioni, Carranza Mellana, Brusaferri, Silvestri, Bertoldo, Schubert, Nettis, Mondelli, Howes, Turkheimer, Bottlaender, Bodini, Stankoff, Loggia and Veronese.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of mean cortex K₁ and R₁ estimates. Panel A,B show, respectively, the distribution across subjects of mean cortex K₁ and R₁ estimates computed via each of the aforementioned methods (2T4K-C_p, 1T1K-C_p, 1T1K-C_b, 1T1K-IDIF); panel C,D show the Bland Altman plots for the comparison between the results of each of the reduced methodologies (1T1K-C_p, 1T1K-C_b, 1T1K-IDIF) and the standard-reference 2T4K-C_p estimates for K₁ and R₁ respectively; results are shown in different colors for the three PET centers (KCL, MGH, ICM).