Table 1.

Concerns about heritable (germline) human genome editing

Concerns common to all applications	Concerns specific to applications other than preventing transmission of genetic variants known to be associated with serious illness or disability
Disrespect of DNA as human heritage Challenging God’s role in creation Lack of informed consent by the child and future generations affected by the editing Negative impact on individuals with disabilities related to genetic variants Perceptions of parental negligence for deciding against performing genome editing	Commodification of children Creation of social pressure to modify children to maintain a level playing field with children modified by other parents Exacerbation of social inequality based on access to the technology Unknown and unpredictable risks of creating novel genome modifications Potential to create harm that will extend to multiple generations Potential for state-imposed eugenic applications Potential for criminal applications