Table 2.
Clinico-genomic characteristics of patients with NonSqNSCLC stratified by smoking history.
| Clinico-genomic characteristics | Smoking status known (N = 8747) | Former or current smoker (N = 7081) | Never-smoker (N = 1666) | P |
|---|---|---|---|---|
| Age at diagnosis (years), median (IQR) | 67.0 (60.0;74.0) | 68.0 (60.0;74.0) | 66.0 (57.0;74.0) | <.001 |
| Age at diagnosis (categorical), n (%) | ||||
| <45 | 192 (2.2%) | 97 (1.4%) | 95 (5.7%) | <.001 |
| ≥45 | 8555 (97.8%) | 6984 (98.6%) | 1571 (94.3%) | |
| Sex, n (%) | ||||
| Female | 4801 (54.9%) | 3682 (52.0%) | 1119 (67.2%) | <.001 |
| Male | 3946 (45.1%) | 3399 (48.0%) | 547 (32.8%) | |
| Self-reported race, n (%) | ||||
| Asian | 301 (3.4%) | 126 (1.8%) | 175 (10.5%) | <.001 |
| Black or African American | 595 (6.8%) | 480 (6.8%) | 115 (6.9%) | |
| Hispanic or Latino | 8 (0.1%) | 6 (0.1%) | 2 (0.1%) | |
| Other race | 1207 (13.8%) | 978 (13.8%) | 229 (13.7%) | |
| White | 5807 (66.4%) | 4819 (68.1%) | 988 (59.3%) | |
| Unknown/not documented | 829 (9.5%) | 672 (9.5%) | 157 (9.4%) | |
| AJCC stage at diagnosis, n (%) | ||||
| I | 1055 (12.1%) | 893 (12.6%) | 162 (9.7%) | <.001 |
| II | 700 (8.0%) | 602 (8.5%) | 98 (5.9%) | |
| III | 1639 (18.7%) | 1394 (19.7%) | 245 (14.7%) | |
| IV | 5093 (58.2%) | 3984 (56.3%) | 1109 (66.6%) | |
| Other/unknown/not documented | 260 (3.0%) | 208 (2.9%) | 52 (3.1%) | |
| Practice type, n (%) | ||||
| Academic | 1051 (12.0%) | 784 (11.1%) | 267 (16.0%) | <.001 |
| Academic/community | 498 (5.7%) | 383 (5.4%) | 115 (6.9%) | |
| Community | 7198 (82.3%) | 5914 (83.5%) | 1284 (77.1%) | |
| Socioeconomic status, n (%) | ||||
| 1—Lowest SES | 1199 (13.7%) | 1049 (14.8%) | 150 (9.0%) | <.001 |
| 2 | 1519 (17.4%) | 1298 (18.3%) | 221 (13.3%) | |
| 3 | 1755 (20.1%) | 1446 (20.4%) | 309 (18.5%) | |
| 4 | 1811 (20.7%) | 1430 (20.2%) | 381 (22.9%) | |
| 5—Highest SES | 1694 (19.4%) | 1238 (17.5%) | 456 (27.4%) | |
| Unknown | 769 (8.8%) | 620 (8.8%) | 149 (8.9%) | |
| ECOG PS at diagnosis, n (%) | ||||
| 0 | 1768 (20.2%) | 1416 (20.0%) | 352 (21.1%) | <.001 |
| 1 | 1839 (21.0%) | 1545 (21.8%) | 294 (17.6%) | |
| 2 | 479 (5.5%) | 423 (6.0%) | 56 (3.4%) | |
| 3+ | 121 (1.4%) | 106 (1.5%) | 15 (0.9%) | |
| Unknown | 4540 (51.9%) | 3591 (50.7%) | 949 (57.0%) | |
| Tumor mutational burden (Mut/Mb), n (%) | ||||
| TMB < 10 | 5690 (65.2%) | 4121 (58.3%) | 1569 (94.5%) | <.001 |
| TMB (10-20) | 2029 (23.2%) | 1964 (27.8%) | 65 (3.9%) | |
| TMB ≥ 20 | 1011 (11.6%) | 985 (13.9%) | 26 (1.6%) | |