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. 2024 Jul 23;15:1436717. doi: 10.3389/fimmu.2024.1436717

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Copyright © 2024 De Federicis, Bassani, Chiarelli, Montini, Giordano, Esposito, Riva, Quattrini, Martinelli, Filippi and Farina

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circulating MAIT cells are reduced in primary progressive MS and no other MS forms or ALS. The frequencies of CD161^high and CD161^highVα7.2⁺ MAIT cells among total CD8⁺ T cells and the respective central memory (T_CM, CD45⁺CCR7⁺), effector memory (T_EM, CD45RO⁺CCR7^-) and naïve (CD45RO^-) subsets, were evaluated by multiparametric flow cytometry in 26 RR-MS (mean age 39.81), 19 PP-MS (mean age: 53.61), 14 SP-MS (mean age: 53.93) and 21 ALS patients (mean age: 58.19) (black circles) and compared to age- and sex-matched healthy controls (grey circles) (A, B). Group comparisons were evaluated by unpaired t-test with Welch’s correction in case of unequal variances or Mann-Whitney test in case of non-normal distribution. * p<0.05, ** p<0.01, *** p<0.001.