FIGURE 1.

Worldwide definitions of “rare disease” based on the prevalence or incidence. Several countries define a rare disease as a disease which has an incidence of 1:2000 (Panama, Colombia, Argentina, Singapore, and the European Union). Meanwhile, other countries define rare diseases as fewer than 5 in 10,000 people (Canada and Australia) or other definitions as in the case of the United States (<200,000 people), Brazil (65 in 100,000 people), and Mexico (5 in 10,000 people) (Schouten, 2020). Illustration created in BioRender.com.