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. 2024 Jul 23;12:1413248. doi: 10.3389/fcell.2024.1413248

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Copyright © 2024 Roberts, Arezoumand, Kadar Shahib, Davie and Rastegar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MeCP2 is a global guardian of the chromatin architecture and epigenome integrity. MeCP2 dosage may lead to different outcomes for epigenome integrity. Binding of MeCP2 to 5-mC may hinder TET activity and oxidation of 5-mC. At reduced levels of MeCP2, dysregulated modulation of the epigenome may permit promiscuous DNMT/TET activity at regions typically regulated by MeCP2 binding. On the contrary, increases levels of MeCP2 may disproportionately hinder DNMT/TET activity in the epigenome. Figure is adapted from Rastegar and Davie 2023 (Rastegar and Davie, 2023). Illustration created in BioRender.com.