Fig. 4.

Effect of NE co-infusion with saline vs. APL-13 on lactate levels and cardiac parameters in CLP septic rats. Impact of NE Administration, in concomitance with NS or APL-13, on A Lactate levels, B effective arterial elastance (Ea), C left ventricular end-diastolic volume (LVEDV), D stroke volume (SV), E cardiac output (CO) and F ejection fraction. Data are presented as mean ± SEM, n = 6 to 8. A–C: *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.0001, using non-parametric student’s t tests (Mann Whitney) for unpaired data. A–C: “Control NE” = black bars, “APL-13” = dark grey bars