Table 4.
Changes in Health-Related QOL Evaluation Parameters before and after Empagliflozin and Linagliptin Combination Therapy.
| Variable | Overall (n = 39) |
DPP4i add-on group (n = 20) | SGLT2i add-on group (n = 19) | P |
|---|---|---|---|---|
| Adherence to medication score† | ||||
| Baseline | 7 (6-7) | 7 (6-7) | 7 (6-7) | 0.98‡ |
| 24 weeks | 7 (6-7) | 7 (6-7) | 7 (6-7) | 0.93‡ |
| Change level | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0.64‡ |
| p§ | 0.72 | >0.99 | >0.99 | |
| Geriatric Depression Scale 5, total score | ||||
| Baseline | 1 (0-3) | 1 (0-2) | 0 (0-3) | 0.25‡ |
| 24 weeks | 1 (0-2) | 1 (0-2) | 2 (1-3) | 0.12‡ |
| Change level | 0 (−0.75 to 0) | 0 (−0.5 to 0) | 0 (−1 to 0) | 0.91‡ |
| p§ | 0.32 | 0.35 | 0.50 | |
| International Physical Activity Questionnaire Short Form 2, total physical activity score | ||||
| Baseline | 792 (240-2,919) | 1,053 (478-4,345) | 438 (66-2,772) | 0.050‡ |
| 24 weeks | 720 (240-2,200) | 1,369 (320-3,308) | 540 (135-1,260) | 0.16‡ |
| Change level | 0 (−300-342) | 21 (−573-722.5) | 0 (−172-310) | >0.99‡ |
| p§ | 0.59 | 0.76 | 0.57 | |
Continuous variables are expressed as median (interquartile range (IQR)). †, adherence-medication score was calculated by analyzing questionnaires about medication from the participants. The difference in values between the DPP4i and SGLT2i add-on groups was analyzed using Mann-Whitney U test (‡). Comparison of each value between baseline and 24 weeks was performed using Wilcoxon signed-rank test (§).
DPP4i, dipeptidyl peptidase-4 inhibitor; SGLT2i, sodium-glucose cotransporter-2 inhibitor