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. 2024 Jun 28;27(8):110413. doi: 10.1016/j.isci.2024.110413

Figure 2.

Figure 2

Integrative analysis of differential DNA methylation and gene expression between cisplatin-sensitive and cisplatin-resistant SCLC cell lines

(A) The workflow of bioinformatics analysis. The integrative analysis identifies 18 down-regulated/hypermethylated genes and 44 up-regulated/hypomethylated genes.

(B) Heatmap of the differentially expressed genes between cisplatin-sensitive and cisplatin-resistant SCLC cell lines.

(C) Heatmap of the differentially methylated CpG sites between cisplatin-sensitive and cisplatin-resistant SCLC cell lines.

(D) The distribution of the differentially methylated CpG sites across gene regions.

(E) GO analysis of the differentially expressed genes (top 10 terms).