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. 2024 Jun 28;27(8):110413. doi: 10.1016/j.isci.2024.110413

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© 2024 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

The PCDHB4 gene is associated with SCLC prognosis

(A) Univariate Cox regression identifies 8 genes associated with the OS of SCLC patients.

(B) Multivariate Cox regression identifies 3 independent prognostic genes (HDAC7, PCDHB4, and HSPB3).

(C) Kaplan-Meier curves in 77 SCLC patients based on the expression of HDAC7, PCDHB4, or HSPB3 using the George dataset.

(D) Kaplan-Meier curves in 48 SCLC patients based on the expression of HDAC7, PCDHB4, or HSPB3 using an independent validation dataset GEO: GSE60052.

(E) Boxplot showing the expression of HDAC7, PCDHB4, and HSPB3 in different stages of SCLC. The differences between groups were analyzed by Wilcoxon test and p < 0.05 was considered statistically significant.

(F) Boxplot showing the expression of HDAC7, PCDHB4, and HSPB3 in SCLC tumors and adjacent normal tissues. The differences between groups were analyzed by Wilcoxon test and p < 0.05 was considered statistically significant.