Figure 4.

The correlation of PCDHB4 methylation with its expression and cisplatin resistance in SCLC

(A) Boxplots showing PCDHB4 expression (left panel) and methylation level of CpG sites within the PCDHB4 promoter (middle panel) in cisplatin-sensitive and cisplatin-resistant SCLC cell lines. Correlation plot (right panel) showing the negative correlation between the CpG methylation level and the expression of PCDHB4 in SCLC cell lines. The differences between groups were analyzed by Wilcoxon test and p < 0.05 was considered statistically significant.

(B) Correlation plot (left panel) showing the positive correlation between the PCDHB4 expression and the cisplatin IC50 in SCLC cell lines. Correlation plot (right panel) showing the negative correlation between the PCDHB4 CpG methylation level and the cisplatin IC50 in SCLC cell lines.

(C) Kaplan-Meier curves of SCLC patients treated with platinum-based chemotherapy using the George dataset.