Table 5.

Summary results of all conducted analyses.

Analysis set					Studies, n			Pooled mean difference estimate (%; 95% CI)			Significant heterogeneity
Primary
	Studies with laboratory-measured HbA1ca			20			–0.31 (–0.45 to –0.16)b			Yes
	Studies with laboratory-measured HbA1c, meta-regression										Yes
		High	20			–0.45 (–0.81 to –0.09)b
		Medium	20			–0.29% (–0.48 to –0.11)b
		Low	20			–0.28% (–0.65 to 0.09)c
Subgroups
	High-intensity interventions			4			–0.43 (–0.78 to –0.09)b			No
	Medium-intensity interventions			12			–0.28 (–0.45 to, –0.11)b			Yes
	High- and medium-intensity interventions			16			–0.32 (–0.47 to –0.16)b			Yes
	Low-intensity interventions			4			–0.34 (–0.83 to 0.16)c			No
Sensitivity
	Including nonlaboratory-measured HbA1c studies			23			–0.40 (–0.56 to –0.24)b			Yes
	Excluding continuous glucose monitoring studies			18			–0.31 (–0.47 to –0.15)b			Yes
	Excluding high-risk studies			16			–0.31 (–0.46 to –0.15)b			Yes

^aHbA_1c: glycated hemoglobin A_1c.

^bStatistically significant.

^cNonsignificant.