Figure 1.

The sensitivity of OCSCs to PARPi

(A) The drug-response curves of survival and IC₅₀ values for cell viability were determined after treating 3AO cells, SKOV3 cells, and their sphere cells to various concentrations (0, 1, 10, 100, and 1,000 μM) of olaparib or niraparib or APS (Figure S1), as measured by the CCK-8 assay after 72 h.

(B) 3AO spheres and 3AO cells, and SKOV3 spheres and SKOV3 cells were treated for 48 h with DMSO, olaparib (200 μM, approximately 50% IC₅₀), and niraparib (30 μM, approximately 50% IC₅₀). The findings, represented by a histogram and representative data, depict the apoptotic rates after Annexin V-FITC/PI staining. Error bars indicate the mean ± SD of three independent repetitions, with statistical significance denoted by ∗p < 0.05; ∗∗p < 0.01.