Table 3.

Clinical details of human PCC cases with detected CACNA1H variants.

Panel number	Age (years)	Sex (M/F)	Diagnosis	Size (mm)	Malignant behavior	Follow-up		Other tumors	Other diseases and features	Wild-type PPGL genes
						Time	Outcome			Constitutional	Tumor
Karolinska cohort
6	44	F	PCC	20	No	16.7 y	Alive	Breast cancer	Anosmia, toxic MNG	By WESa	By WESa
19	37	M	PCC	100	No	27 y	Alive	Seminoma neurofibromas	Vertigo	By WESa	By WESa
E2	51	M	PCC	45	No	0 y	Dead	–	––	By WES-panelb	–
TCGA database
TCGA-WB-A81D	82	F	PCC	75	No	4 y	Alive	–	–	By WESc	By WESc
TCGA-QR-A70U	46	F	PCC	57	No	4 y	Alive	–	–	By WESc	By WESc
TCGA-S7-A7WP	25	F	PCC	50	No	2 y	Alive	–	–	By WESc	By WESc

Age, age at diagnosis; F, female; M, male; MNG, multinodular goiter; −, not reported; PCC, pheochromocytoma;WES, whole-exome sequencing; y, years.

^aJuhlin et al. 2015; ^bGene panel detailed in the Supplementary Table 3; ^cFishbein et al. 2017.