Table 1.

Fold changes in plasma amino acids measured by liquid chromatography tandem mass spectrometry analyzed by the matched pairs t-test.

Amino acid	Low-dose glucagon infusion			High-dose glucagon infusion
	Fold change	P-value	q-value	Fold change	P-value	q-value
Arginine	0.71a	0.0052	0.0119	0.45a	0.005	0.0155
Proline	0.58a	0.0044	0.0111	0.29a	0.001	0.0096
Carnosine	0.74a	0.0228	0.0248	0.53a	0.0121	0.0234
3-methyl-L-histidine	0.91	0.2648	0.1232	0.74a	0.0244	0.0349
Tryptophan	0.91	0.1118	0.0684	1.03	0.9273	0.4488
Histidine	0.95	0.396	0.1662	0.61a	0.0055	0.0163
1-Methylhistidine	1.04	0.3436	0.1497	0.81a	0.0783	0.0772
Lysine	0.81a	0.0107	0.017	0.48a	0.0099	0.0217
Ornithine	0.60a	0.0052	0.0118	0.29a	0.0018	0.0104
Phenylalanine	1.07	0.4332	0.176	1	0.9431	0.4507
Tyrosine	0.86	0.2432	0.1168	0.64	0.1115	0.099
Leucine	1.18a	0.0866	0.0575	0.99	0.8222	0.4162
Isoleucine	1.28a	0.0087	0.0156	1.2	0.1799	0.1421
Methionine	0.79a	0.0191	0.0225	0.69	0.0066	0.0171
Cysteine	0.9	0.6157	0.2192	0.54a	0.0207	0.0317
Valine	1.20a	0.0698	0.0507	0.87	0.3189	0.2206
Citrulline	0.82a	0.0088	0.0156	0.54a	0.006	0.0166
Alanine	0.51a	0.0182	0.0221	0.30a	0.0019	0.0104
Glycine	0.70a	0.0215	0.024	0.43a	0.004	0.0145
Glutamine	0.98	0.6834	0.2359	0.57a	0.0115	0.0231
Glutamic Acid	0.69*	0.0172	0.0213	0.50a	0.0083	0.0191
Asparagine	0.8	0.0681	0.0503	0.42a	0.0012	0.0101
Serine	0.72a	0.01	0.0164	0.46a	0.0015	0.0102
Threonine	0.65a	0.0033	0.0095	0.32a	0.0024	0.0115
Aspartic acid	0.40a	0.0007	0.0074	0.40a	0.0123	0.0235
Taurine	0.55a	0.001	0.0074	0.48a	0.0015	0.0102

^a P < 0.05.