Table 2.

Fold changes in plasma monoacylglycerol and diacylglycerols measured by liquid chromatography–tandem mass spectrometry analyzed by the matched pairs t-test.

Lipid	Low-dose glucagon infusion			High-dose glucagon infusion
	Fold change	P-value	q-value	Fold change	P-value	q-value
1-Myristoylglycerol (14:0)	0.14a	0.0067	0.0133	0.10a	0.0008	0.0093
1-Palmitoleoylglycerol (16:1)b	0.25	0.1147	0.0693	0.09a	0.0009	0.0096
1-Oleoylglycerol (18:1)	0.32a	0.0321	0.0312	0.14a	0.0009	0.0096
1-Linoleoylglycerol (18:2)	0.35	0.0956	0.0614	0.20a	0.0023	0.0115
1-Arachidonylglycerol (20:4)	1.55	0.0685	0.0503	1.18	0.976	0.4584
1-Docosahexaenoylglycerol (22:6)	1.78	0.0758	0.0527	1.54	0.4649	0.2925
2-Oleoylglycerol (18:1)	0.39	0.0917	0.0596	0.32a	0.0008	0.0096
2-Arachidonoylglycerol (20:4)	1.48	0.1485	0.0827	1.54	0.0686	0.0699
Palmitoyl-linoleoyl-glycerol (16:0/18:2) [1]b	0.73	0.2539	0.1205	0.29a	0.0014	0.0102
Palmitoyl-linoleoyl-glycerol (16:0/18:2) [2]b	0.57a	0.0072	0.0139	0.31a	0.0048	0.0155
Palmitoyl-arachidonoyl-glycerol (16:0/20:4) [1]b	0.53	0.0971	0.0621	0.58	0.0567	0.0623
Palmitoyl-arachidonoyl-glycerol (16:0/20:4) [2]b	0.63a	0.0365	0.0334	0.52a	0.0042	0.0149
Palmitoleoyl-arachidonoyl-glycerol (16:1/20:4) [2]b	0.40a	0.0112	0.0173	0.35a	0.0201	0.0315
Oleoyl-linoleoyl-glycerol (18:1/18:2) [1]	0.50a	0.002	0.0083	0.34a	0.0116	0.0231
Oleoyl-linoleoyl-glycerol (18:1/18:2) [2]	0.49a	0.0009	0.0074	0.32a	0.0162	0.0278
Linoleoyl-linoleoyl-glycerol (18:2/18:2) [1]b	0.51a	0.0188	0.0224	0.30a	0.0232	0.034
Linoleoyl-linoleoyl-glycerol (18:2/18:2) [2]b	0.54a	0.0062	0.0131	0.34a	0.0135	0.025
Linoleoyl-linolenoyl-glycerol (18:2/18:3) [2]b	0.53a	0.0045	0.0111	0.29a	0.004	0.0145
Stearoyl-arachidonoyl-glycerol (18:0/20:4) [1]b	1.14	0.216	0.1085	1.19	0.3159	0.2192
Stearoyl-arachidonoyl-glycerol (18:0/20:4) [2]b	1.21a	0.0402	0.0361	1.33	0.1205	0.1052
Oleoyl-arachidonoyl-glycerol (18:1/20:4) [1]b	0.63	0.0807	0.0544	0.6	0.0929	0.0877
Oleoyl-arachidonoyl-glycerol (18:1/20:4) [2]b	0.7	0.1241	0.0736	0.50a	0.0124	0.0236
Linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]b	0.52	0.1188	0.0711	0.48	0.1957	0.1517
Linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]b	0.74	0.204	0.1044	0.43a	0.0128	0.0241
Linoleoyl-docosahexaenoyl-glycerol (18:2/22:6) [1]b	1.47	0.2702	0.1246	1.03	0.8762	0.4341
Linoleoyl-docosahexaenoyl-glycerol (18:2/22:6) [2]b	1.46	0.052	0.0419	0.83	0.3881	0.2551

Brackets with numbers indicate the presence of isomers of other compounds in the spectral library.

^a P < 0.05.

^bIndicates a compound that has not been confirmed based on a standard, but metabolon is confident in its identity.