Table 4.

Fold changes in plasma purines measured by liquid chromatography–tandem mass spectrometry analyzed by the matched pairs t-test.

Purine metabolite	Low-dose glucagon infusion			High-dose glucagon infusion
	Fold change	P-value	q-value	Fold change	P-value	q-value
Inosine	0.87	0.7714	0.253	1.94a	0.0024	0.0115
Hypoxanthine	0.91	0.9261	0.2864	1.71	0.1581	0.1287
Xanthine	0.65	0.4488	0.1799	0.99	0.9881	0.4608
Xanthosine	0.54a	0.0111	0.0173	0.61	0.0873	0.0835
N1-methylinosine	0.99	0.994	0.3003	0.81	0.4837	0.3006
Urate	0.67a	0.0046	0.0111	0.95	0.5877	0.3398
Allantoin	0.79a	0.0023	0.0083	0.68a	0.0146	0.0261
Allantoic acid	0.82a	0.0066	0.0133	0.73	0.0599	0.064
1-Methylhypoxanthine	0.74	0.2394	0.1157	0.66	0.0536	0.0603
Adenosine 5′-monophosphate	1.22	0.5287	0.1993	1.63	0.1194	0.1044
Adenosine	1.07	0.6616	0.23	1.9	0.0573	0.0626
Adenine	0.95	0.7647	0.252	0.8	0.1549	0.1264
N1-methyladenosine	0.92a	0.0382	0.0349	0.96	0.6518	0.3604
N6-carbamoylthreonyladenosine	0.85	0.0631	0.0481	0.72a	0.0302	0.0409
N6-succinyladenosine	0.99	0.6466	0.226	0.92	0.4729	0.2968
Guanosine	0.66	0.7964	0.2592	2.93a	0.0078	0.0184
Guanine	1.05	0.5186	0.1974	2.82a	0.0039	0.0145
7-Methylguanine	0.73a	0.0055	0.0123	0.67a	0.004	0.0145
N2,N2-dimethylguanosine	0.82	0.0734	0.0519	0.80a	0.0205	0.0316

^aP < 0.05.