Table 4.

Univariate and multivariate Cox regression analysis of OS on the variables tested.

Variable	RMTC patients				PMTC patients
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
PET/CT results	2.154 (1.129–4.110)	0.020	3.006 (1.010–8.948)	0.048	0.999 (0.307–3.253)	0.998	–	–
MTV	1.012 (1.005–1.018)	0.001	1.016 (1.002–1.030)	0.021	1.002 (1.001–1.003)	0.007	1.002 (1.000–1.004)	0.041
SUVmax	1.032 (0.996–1.069)	0.086	0.984 (0.908–1.066)	0.686	0.998 (0.949–1.050)	0.947	–	–
SUVmean	1.137 (0.978–1.321)	0.094	0.863 (0.596–1.249)	0.434	1.119 (0.887–1.412)	0.343	–	–
SMTC and HMTC	3.220 (0.990–10.479)	0.052	2.595 (0.785–8.580)	0.118	0.709 (0.251–2.003)	0.516	–	–
Stage	1.100 (0.957–1.265)	0.179	–	–	1.057 (0.830–1.347)	0.654	–	–
bCt	1.000 (1.000–1.000)	0.036	1.000 (1.000–1.000)	0.316	1.000 (1.000–1.000)	0.054	1.000 (1.000–1.000)	0.711
Age	1.004 (0.984–1.024)	0.699	–	–	1.034 (1.004–1.065)	0.026	1.039 (1.008–1.071)	0.014
Gender	0.811 (0.442–1.488)	0.498	–	–	0.739 (0.390–1.400)	0.353	–	–

bCt, basal calcitonin; HMTC, hereditary MTC; MTV, metabolic tumor volume; PMTC, primary MTC; RMTC, recurrent MTC; SMTC, sporadic MTC; SUV_max, maximum standardized uptake value; SUV_mean, mean standardized uptake value; –, not determined.