Table 4.

Recommendations for screening in patients with PWS at diagnosis and throughout life.

Item		Diagnosis	Childhood	Transition
Endocrine	Growth hormone stimulation test	No	No	Noa
	Adrenal function testing	No	Only if clinical suspicion	Only if clinical suspicion
	Thyroid function	Yes	Annually	Annually
Cardiorespiratory	Full sleep study	Yes	2–3 months after initiation of GH Every 2–3 years	If concerns
	Overnight pulse oximetry	No	Annual	No
Bone	Spinal X-ray	Yes	Every 2 years (once sitting) until age 5 years and at age 10 years and during puberty	Yes
	DXA bone scan	No	No	Yes
Blood monitoring	IGF-1, TFTs, FBC, nutrition screena, PTH, renal function, liver function, bone profile, vitamin D, FSHc, LHc, testosterone/oestrogenc (IGF-BP3 and inhibin Bc – where available)	Yes	Annual	Annual

^aThis will vary depending on local centres; ^bEvaluation of the GH axis can be considered in adult services; ^cWhen age appropriate.