Table 2. Results of emplace_local searches for megabody in complex with GABA receptor.

Megabody copy	Sphere shift† (Å)	Rotation eLLG‡	Top rotation LLG§	Correct rotation LLG¶	Correct RFZ††	Final LLG	Run time (s)
1	0	54.7	−13.4 (4)	−13.4 (1)	5.63	805	58.4
2	0	55.5	−15.3 (11)	−15.3 (1)	5.24	536	54.7
3	0	54.6	−11.9 (3)	−11.9 (1)	5.90	540	56.6
4	0	54.8	−12.6 (6)	−12.6 (1)	5.62	523	56.3
5	0	54.5	−12.1 (5)	−12.1 (1)	5.80	533	55.9
1	−9	68.1	−38.6 (55)	— (—)	—	14	182.8
1	−6	64.7	−32.4 (37)	−38.3 (16)	3.57	548	99.5
1	−3	60.7	−27.4 (33)	−27.4 (1)	4.52	547	57.9
1	+3	51.5	5.8 (1)	5.8 (1)	7.57	505	56.3
1	+6	51.3	18.6 (1)	18.6 (1)	8.81	505	55.4
1	+9	53.6	31.7 (1)	31.7 (1)	9.89	505	54.7

^†Shift of the search sphere relative to the fivefold rotation axis.

^‡Expected log-likelihood-gain (eLLG) score for the rotation search (Read et al., 2023 ▸).

^§Top log-likelihood-gain score from the rotation search (number of accepted orientations in parentheses).

^¶Log-likelihood-gain score for correct orientation (position in search list in parentheses).

^††Rotation-function Z-score for the correct orientation.