Fig. 1.

Differences in standardized values of each continuous variable by LCA derived subphenotypes. The variables are sorted based on the degree of separation between the subphenotypes, from maximum positive separation on the left (i.e., subphenotype 2 higher than subphenotype 1) to maximum negative separation on the right (i.e., subphenotype 2 lower than subphenotype 1). The y-axis describes the standardized variable values, in which all means are scaled to zero and standard deviations (SDs) to one. A value of + 1 for the investigated standardized variable means that the mean value for a given subphenotype was one SD higher than the mean value in the cohort as a whole. Mean values are joined by lines to facilitate displaying subphenotype profiles. Variables included to investigate LCA derived subphenotypes are highlighted in green (CT-derived features) and red (clinical and laboratory parameters). WBC white blood cells, CRP C-reactive protein, PaCO₂ arterial carbon dioxide partial pressure, PaO₂/FiO₂ ratio of arterial oxygen partial pressure to fractional inspired oxygen