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Replication kinetics of tissue-derived HIV-1 isolates obtained at autopsy from different tissue compartments of patients with AIDS, after infection of 5-day-old MDM (A), monocytes (B), and T lymphocytes (C). (Top) HIV-1 replication as assessed by p24 antigen ELISA (Coulter Electronics) in culture supernatants on days 0, 7, and 14 after infection (error bars represent standard deviation; P < 0.05). (Bottom) DNA PCR products for full-length HIV DNA on days 7 and 14 of infection.
