TABLE 1.
Phenotypic characteristics of blood and tissue HIV-1 primary isolates from patients at different stages of infection and their level of replication in monocytes, macrophages, and T lymphocytes as measured by EC p24 antigen levels
| Isolate | Stage of diseasea (category) | CD4 countsb | Level of replication
inc:
|
MT-2 cell assay | CPE in PBMC | ||
|---|---|---|---|---|---|---|---|
| Monocytes | Macrophages | Lymphocytes | |||||
| NB1 | IV | <50 | ++ | +++ | +++ | NSI | − |
| NB2 | IV | <50 | ++ | +++ | +++ | NSI | − |
| NB3 | IV | <50 | ++ | +++ | +++ | SI | +++ |
| NB4 | IV | <50 | ++ | +++ | +++ | NSI | − |
| NB5 | IV | <100 | − | +++ | +++ | SI | ++ |
| NB6 | IV | <50 | − | +++ | +++ | NSI | + |
| NB7 | IV | <50 | + | +++ | +++ | NSI | − |
| NB8 | IV | <50 | ++ | +++ | ++ | NSI | − |
| NB9 | IV | <100 | − | ++ | +++ | NSI | + |
| NB10 | IV | <50 | ++ | ++ | ++ | NSI | + |
| NB11 | IV | <50 | + | ++ | +++ | NSI | − |
| NB12 | IV | 200 | − | ++ | +++ | NSI | + |
| NB13 | IV | <50 | − | + | +++ | NSI | + |
| NB14 | IV | <50 | − | + | ++ | NSI | − |
| NB15 | IV | <100 | − | + | ++ | NSI | + |
| NB16 | IV | <50 | − | − | ++ | NSI | + |
| NB17 | IV | 200 | − | + | +++ | NSI | − |
| NB18 | IV | <50 | ++ | +++ | +++ | NSI | − |
| NB19 | IV | <100 | + | ++ | ++ | NSI | − |
| NB20 | II | 200 | − | +++ | +++ | NSI | − |
| NB21 | II | 250 | − | +++ | +++ | SI | +++ |
| NB22 | II | 550 | + | ++ | +++ | NSI | − |
| NB23 | II | 600 | − | + | +++ | NSI | + |
| NB24 | II | 650 | − | − | ++ | NSI | + |
| NB25 | II | 500 | − | − | +++ | NSI | + |
| NB26 | I | >750 | − | + | +++ | NSI | − |
| NB27 | I | >750 | + | + | +++ | NSI | − |
| HIV-BaL | NA | NA | ++ | +++ | +++ | NSI | − |
| HIV-JRFL | NA | NA | + | +++ | +++ | NSI | − |
| NT1 | IV | <50 | ++ | + | +++ | NSI | − |
| NT2 | IV | <50 | +++ | +++ | +++ | NSI | + |
| NT3 | IV | <50 | ++ | ++ | +++ | NSI | − |
| NT4 | IV | <50 | − | − | + | NSI | − |
| NT5 | IV | <50 | +++ | +++ | +++ | NSI | ++ |
| NT6 | IV | <50 | +++ | +++ | +++ | NSI | ++ |
| NT7 | IV | <50 | − | ++ | ++ | NSI | + |
| NT8 | IV | <50 | + | +++ | +++ | NSI | − |
| NT9 | IV | <50 | ++ | +++ | +++ | NSI | − |
| NT10 | IV | <50 | + | ++ | +++ | NSI | − |
According to CDC classification (category IV, AIDS; category II, asymptomatic; category I, acute seroconversion).
Absolute count of CD4 lymphocytes per microliter of blood at the time of virus isolation.
Level of replication: −, no productive infection; +, low (<1 ng/ml); ++, intermediate (1 to 49 ng/ml), +++, high (>50 ng/ml).