Viral quantification of SARS-CoV-2 sub-genomic RNA (sgE), relative to 18S, using qRT-PCR from nasal turbinate (a) and lung (b) samples harvested from each group on days 4 and 6 post-infection. Mice infected with the Delta variant were administered with a single IP dose of either saline (n = 12) or Ronapreve, 400 µg/mouse, in saline (n = 16). Equally, mice infected with the Omicron variant were administered with a single IP dose of either saline (n = 16) or Ronapreve, 400 µg/mouse, in saline (n = 16). Data for individual animals are shown with the mean value represented by a black line. NS, not significant; *, P ≤ 0.05 (unpaired, two-tailed t-test).