TABLE 1.

Mean Ronapreve (casirivimab and imdevimab) concentrations in mouse plasma at 4 and 6 dpi^a

SARS-CoV-2 variant	Mean casirivimab plasma concentration ± SD (µg/mL)				Mean imdevimab plasma concentration ± SD (µg/mL)
	4 dpi		6 dpi		4 dpi		6 dpi
	Vehicle control	Ronapreve (400 µg)	Vehicle control	Ronapreve (400 µg)	Vehicle control	Ronapreve (400 µg)	Vehicle control	Ronapreve (400 µg)
Delta (B.1.617.2)	<LLQ	28.09 ± 0.38	<LLQ	28.74 ± 5.04	<LLQ	43.94 ± 3.12	<LLQ	41.80 ± 4.88
Omicron (B.1.1.529/BA.1)	<LLQ	27.76 ± 0.72	<LLQ	34.40 ± 4.29	<LLQ	46.90 ± 3.34	<LLQ	40.88 ± 0.93
Unpaired t-test	-	P = 0.315	-	P = 0.887	-	P = 0.127	-	P = 0.661

^a Mice were inoculated with 10³ PFU of SARS-CoV-2 Delta or Omicron and treated with a single intraperitoneal dose of the saline vehicle control or 400 µg Ronapreve in saline. Quantitative detection of each monoclonal antibody was completed separately using ELISA. <LLQ, below the lower limit of quantification.