TABLE 4.
Chimeric virus rABcp248/404/1030 is protective against challenge with rAB in the upper and lower respiratory tracts of chimpanzees
| Immunizing virusa | Inoculum dose | No. of chimpanzees | Mean virus titer following RSV challenge (log10PFU/ml)
|
Peak rhinorrhea scoreb | |||||
|---|---|---|---|---|---|---|---|---|---|
| Nasopharyngeal swab
|
Tracheal lavage
|
||||||||
| Day 3 | Day 5 | Day 7 | Day 3 | Day 5 | Day 7 | ||||
| rABcp248/404/1030 | 5.0 | 2 | <0.7 ± 0.00 | 1.00 ± 0.40 | <0.7 ± 0.00 | <0.7 ± 0.00 | <0.7 ± 0.00 | <0.7 ± 0.00 | 0 |
| None | 4 | 3.12 ± 0.16 | 3.72 ± 0.14 | 4.28 ± 0.12 | <0.7 ± 0.00 | 3.78 ± 0.26 | 3.80 ± 0.15 | 3 | |
a
Chimpanzees were inoculated by the intranasal and intratracheal routes with the indicated amount of virus in a 1-ml dose per site. After 28 days, the chimpanzees were administered 5.0 log10PFU of rAB by the intranasal and intratracheal routes. Nasopharyngeal-swab and tracheal-lavage samples were then collected after 3, 5, and 7 days.
b
The amount of rhinorrhea was estimated daily and assigned a score (0 to 4) that indicated extent and severity: 0, none; 1, trace; 2, mild; 3, moderate; 4, severe.