Table 5. HUB Genes from STITCH Database Associated with Endometriosis (EMS) with Their Roles a.
| Identifier | Name | PDB ID | Confidence score | Possible Role |
|---|---|---|---|---|
| BAD | BCL2-associated agonist of cell death | NA | 0.962 | Promotes cell death. |
| BCL2 | B-cell CLL/lymphoma 2 | 2Xa0 (ChainA) | 0.944 | Suppresses apoptosis in a variety of cell systems |
| BCL2L11 | BCL2-like 11 | NA | 0.840 | Apoptosis facilitator |
| BECN1 | Beclin 1, autophagy related; | NA | 0.866 | Plays a central role in autophagy |
| CCNA1 | Cyclin A1 | NA | 0.997 | Involved in the control of the cell cycle at the G1/S |
| CCNA2 | Cyclin A2 | 2x1n | 0.898 | Essential for the control of the cell cycle at the G1/S |
| CCNB1 | Cyclin B1 | NA | 0.993 | Essential for the control of the cell cycle at the G2/M |
| CDC25C | Cell division cycle 25 homolog C (S. pombe) | NA | 0.713 | Functions as a dosage-dependent inducer |
| CDH17 | Cadherin 17 | NA | 0.949 | Calcium-dependent cell adhesion proteins. |
| CDK1 | Cyclin-dependent kinase 1 | NA | 0.999 | Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle |
| CDK7 | Cyclin-dependent kinase 7 | 1ua2 | 0.957 | Involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. |
| CTNNA1 | Catenin (cadherin-associated protein), alpha 1, 102kDa | NA | 0.934 | Associates with the cytoplasmic domain of a variety of cadherins |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88kDa | NA | 0.987 | Key downstream component of the canonical Wnt signaling pathway. |
| EGF | Epidermal growth factor | 1nql | 0.900 | EGF stimulates the growth of various epidermal and epithelial tissues |
| GAS6 | Growth arrest-specific 6 | 1h30 (Chain A) | 0.900 | Implicated in cell growth and survival, cell adhesion and cell migration. |
| MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | NA | 0.996 | |
| RIPK1 | Receptor (TNFRSF)-interacting serine-threonine kinase 1 | NA | 0.995 | Transduces inflammatory and cell-death signals (programmed necrosis) f |
| TAB1 | TGF-beta activated kinase 1 | NA | 0.969 | Play an important role in mammalian embryogenesis |
| TAB2 | TGF-beta activated kinase 2 | 2wwz (Chain C) | 0.995 | Promotes MAP3K7 activation in the IL1 signaling pathway. |
a Key molecular players associated with EMS, providing information on PDB ID (if available), confidence score, and possible roles in cellular processes are presented.