Table 2. Input Parameters of Decision Tree Model.

Parameter	Probability	95% Confidence Interval (CI)	References
Probabilities
INR in range (in standard dosing group)	0.44	0.242 - 0.634	(18)
INR in range (in genotype - guided dosing group)	0.562	0.37 - 0.754	(18)
INR out of range (in standard dosing group)	0.56	calculated	(18)
INR out of range (in genotype - guided dosing group)	0.438	calculated	(18)
Thromboembolism (within therapeutic INR range)	0.02	0.01 - 0.03	(23)
Thromboembolism (out of therapeutic INR range)	0.06	0.03 - 0.1	(23)
Bleeding (within therapeutic INR range)	0.027	0.013 - 4.02	(23)
Bleeding (out of therapeutic INR range)	0.093	0.022 - 0.093	(23)
ICH	0.29	0.23 - 0.35	(25)
ECH	0.71	-	(25)
Stroke	0.6	0.48 - 0.72	(25)
TIA	0.4	-	(25)
Utilities
Standard dosing	0/696	0.458 - 0.934	Calculated
Genotype - guided dosing	0/760	0.524 - 0.996	Calculated
ICH	- 0.14	- 0.12 to - 0.16	(25)
ECH	- 0.06	- 0.02 to - 0.1	(25)
TIA	- 0.103	- 0.088 to - 0.119	(25)
Stroke	- 0.14	- 0.12 to - 0.16	(25)
Sequelae	- 0.374	- 0.16 to - 0.374	(25)
Death	0.0	-	(25)
Costs
Genotyping	187.5	-	National tariffs
INR monitoring	16	-	National tariffs
ICH	241	-	National tariffs
ECH	205	-	National tariffs
TIA	178	-	National tariffs
Stroke	311	-	National tariffs
Sequelae	21.5	-	National tariffs

Abbreviations: ECH, extracranial haemorrhage; ICH, intracranial haemorrhage; INR, international normalized ratio; TIA transient ischemic attack.