Table 1.
Serum analytes showing a correlation with IFNα protein levels and IFN 21-gene signature expression in patients with systemic lupus erythematosus*
| Analyte† | IFNα | 21-IFNGS | ||||||
|---|---|---|---|---|---|---|---|---|
| No. | Rho | P | FDR | No. | Rho | P | FDR | |
| IFN and IFN-inducible cytokines | ||||||||
| 21-IFNGS | 255 | 0.82 | <10−14 | <10−14 | – | – | – | – |
| IFNα | – | – | – | - | 255 | 0.82 | <10−14 | <10−14 |
| MCP-2 | 256 | 0.65 | <10−14 | <10−14 | 301 | 0.67 | <10−14 | <10−14 |
| IP-10 | 256 | 0.63 | <10−14 | <10−14 | 301 | 0.63 | <10−14 | <10−14 |
| BAFF | 256 | 0.62 | <10−14 | <10−14 | 301 | 0.57 | <10−14 | <10−14 |
| MIP-3β | 256 | 0.60 | <10−14 | <10−14 | 301 | 0.63 | <10−14 | <10−14 |
| I-TAC | 256 | 0.59 | <10−14 | <10−14 | 301 | 0.56 | <10−14 | <10−14 |
| BLC | 256 | 0.43 | 3.49 × 10−13 | 2.48 × 10−12 | 301 | 0.43 | 4.44 × 10−15 | 3.61 × 10−14 |
| MCP-1 | 256 | 0.37 | 7.48 × 10−10 | 4.03 × 10−9 | 301 | 0.34 | 1.54 × 10−9 | 7.93 × 10−9 |
| Eotaxin 2 | 256 | −0.23 | 1.88 × 10−4 | 6.21 × 10−4 | 301 | −0.21 | 1.84 × 10−4 | 6.10 × 10−4 |
| Vascular damage/lipid dysregulation | ||||||||
| TNF | 254 | 0.62 | <10−14 | <10−14 | 253 | 0.61 | <10−14 | <10−14 |
| IL-10 | 254 | 0.55 | <10−14 | <10−14 | 253 | 0.51 | <10−14 | <10−14 |
| Angiopoietin 2 | 256 | 0.52 | <10−14 | <10−14 | 301 | 0.47 | <10−14 | <10−14 |
| VCAM-1 | 256 | 0.49 | <10−14 | <10−14 | 301 | 0.47 | <10−14 | <10−14 |
| vWF | 255 | 0.32 | 1.42 × 10−7 | 6.35 × 10−7 | 300 | 0.33 | 6.37 × 10−9 | 3.15 × 10−8 |
| Apo A-I | 50 | −0.33 | 0.021 | 0.044 | 50 | −0.37 | 0.009 | 0.021 |
| Medium HDL particle count | 50 | −0.34 | 0.015 | 0.032 | 50 | −0.36 | 0.010 | 0.023 |
| HDL cholesterol | 50 | −0.37 | 0.009 | 0.020 | 50 | −0.41 | 0.003 | 0.009 |
| Total cholesterol | 50 | −0.39 | 0.005 | 0.013 | 50 | −0.39 | 0.005 | 0.012 |
| HDL in the H3P size range | 50 | −0.50 | 2.07 × 10−4 | 6.81 × 10−4 | 50 | −0.46 | 8.69 × 10−4 | 0.003 |
| Neutrophil dysregulation | ||||||||
| Progranulin | 256 | 0.62 | <10−4 | <10−14 | 301 | 0.57 | <10−14 | <10−14 |
| CitH3–DNA | 185 | 0.23 | 0.001 | 0.004 | 188 | 0.22 | 0.002 | 0.006 |
| MPO–DNA | 185 | 0.19 | 0.008 | 0.020 | 188 | 0.21 | 0.003 | 0.009 |
| Neutrophil number | 251 | −0.29 | 2.13 × 10−6 | 8.89 × 10−6 | 296 | −0.18 | 0.002 | 0.005 |
| Immune dysregulation/other | ||||||||
| β2-microglobulin | 255 | 0.52 | <10−14 | <10−14 | 300 | 0.52 | <10−14 | <10−14 |
| Ficolin 3 | 256 | 0.45 | 3.02 × 10−14 | 2.28 × 10−13 | 301 | 0.48 | <10−14 | <10−14 |
| IL-2 | 253 | 0.43 | 6.89 × 10−13 | 4.75 × 10−12 | 252 | 0.40 | 2.37 × 10−11 | 1.44 × 10−10 |
| IFNγ | 256 | 0.42 | 1.67 × 10−12 | 1.08 × 10−11 | 255 | 0.46 | 1.04 × 10−14 | 8.17 × 10−14 |
| IgE | 256 | 0.37 | 1.22 × 10−9 | 6.40 × 10−9 | 301 | 0.33 | 6.37 × 10−9 | 3.15 × 10−8 |
| TRAIL-R3 | 256 | −0.22 | 5.11 × 10−4 | 0.002 | 301 | −0.24 | 2.20 × 10−5 | 8.08 × 10−5 |
| IL-1RII | 256 | −0.36 | 4.08 × 10−9 | 2.05 × 10−8 | 301 | −0.29 | 4.09 × 10−7 | 1.80 × 10−6 |
| Leukocyte number | 251 | −0.41 | 7.62 × 10−12 | 47.9 × 10−11 | 296 | −0.33 | 9.53 × 10−9 | 4.63 × 10−8 |
| Lymphocyte number | 251 | −0.48 | 1.33 × 10−15 | 1.09 × 10−14 | 296 | −0.49 | <10−14 | <10−14 |
IFNα = interferon-α; 21-IFNGS = 21-gene type I IFN gene signature; MCP-2 = monocyte chemotactic protein 2; IP-10 = IFNγ-inducible 10-kd protein; MIP-3β = macrophage inflammatory protein 3β; I-TAC =IFN-inducible T cell α chemoattractant; BLC = B lymphocyte chemoattractant; TNF = tumor necrosis factor; IL-10 = interleukin-10; VCAM-1 = vascular cell adhesion molecule 1; vWF = von Willebrand factor; Apo A-I = apolipoprotein A-I; HDL = high-density lipoprotein; CitH3–DNA = citrullinated histone H3–DNA; MPO–DNA = myeloperoxidase–DNA; IL-1RII = IL-1 receptor type II.
Includes analytes measured with a P value of <0.05 and a false discovery rate (FDR) of <0.05.