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. 2024 Aug 5;13(1):2384667. doi: 10.1080/2162402X.2024.2384667

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 3. — Immunohistochemistry (IHC) analysis for the four MMR proteins in the DLBCL-NOS cohort.

(a) Left: a scatter plot showing the distribution (each dot represents one patient) and median (indicated by horizontal lines) IHC scores (percentage of tumor cells) of the four MMR proteins in DLBCL-NOS cases. MSH6 had a significantly lower median expression score than other three MMR proteins. Right: a case distribution plot (each column represents one patient) showing the overlaps between MSH2^high and MSH6^high cases and between MLH1^high and PMS2^high cases in DLBCL-NOS cases scored for all the four MMR proteins. Cutoff for high expression of each MMR protein: the median IHC score. (b) Scatter plots for MMR protein IHC scores in the DLBCL cell-of-origin subtypes (subtyped by GEP). Each dot represents one patient with DLBCL-NOS and bars indicate mean values. The ABC subtype had significantly higher mean levels of MLH1 and PMS2 protein expression than the GCB subtype and unclassifiable (U.C) DLBCL-NOS. Unclassified cases had significantly lower mean MSH2 expression than both ABC and GCB subtypes. P values are by unpaired t test (two tailed). (c) MSH6, PMS2, and MLH1 expression in DLBCL-NOS cases showed differences between ecotyper-assigned subtypes based on the most abundant B cell state in each DLBCL sample. (c) EBV+ DLBCL had lower mean MSH6 and PMS2 IHC scores than EBV-negative DLBCL by unpaired t test.