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. 2024 Aug 5;13(1):2384667. doi: 10.1080/2162402X.2024.2384667

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 5. — Gene-expression profiling analysis for high vs. low expression of MMR proteins in DLBCL-NOS.

(a) Top: Heatmap visualization for significantly downregulated genes (false discovery rate (FDR) < 0.01 and fold change ≥ 1.5) and upregulated genes in MutSα^high DLBCLs (FDR <0.05 and fold change ≥ 1.4). Bottom: Heatmap to visualize significantly downregulated genes (FDR <0.01) and upregulated genes (FDR ≤0.02) in MutLα^high DLBCLs. (b) Cell state and ecosystem subtype analysis by the Ecotyper software and comparisons for DLBCLs with low vs. high expression of MSH6 (cutoff for MSH6^high: >70%). Top: Scatter plots for fractions of B-cell states and ecotypes in MSH6^high and MSH6^low DLBCLs. Bottom: Scatter plots for abundance of cell states comprising the LE4 and LE7 ecotypes. Colors of labels for cell states and ecotypes indicate their associated prognostic effects by Reference 37. Abbreviation: S, state; LE, lymphoma ecosystem type, MΦ, macrophage; Treg, regulatory T cell; NK, natural killer cell; T_FH, follicular helper T cell; EC, endothelial cell; DC, dendritic cell. Reddish colors indicate unfavorable prognostic effects, greenish colors indicate favorable prognostic effects, and black color indicates no significant prognostic effect. Significance: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.