Table 5.
Mendelian randomization result of casual effects between gut microbiome and the risk of depression.
| Group | Bacterial | Nsnp | Methods | SE | OR (95% CI) | P-value |
|---|---|---|---|---|---|---|
| Phylum | Lentisphaerae | 9 | Inverse variance weighted | 0.002 | 1.004(1.000,1.007) | 0.035 |
| MR Egger | 0.007 | 1.008(0.995,1.021) | 0.261 | |||
| Simple mode | 0.004 | 1.001(0.994,1.009) | 0.725 | |||
| Weighted median | 0.002 | 1.003(0.998,1.007) | 0.266 | |||
| Weighted mode | 0.004 | 1.002(0.995,1.009) | 0.626 | |||
| Class | Lentisphaeria | 12 | Inverse variance weighted | 0.002 | 1.004(1.001,1.008) | 0.019 |
| MR Egger | 0.007 | 1.009(0.996,1.022) | 0.227 | |||
| Simple mode | 0.004 | 1.002(0.995,1.010) | 0.533 | |||
| Weighted median | 0.002 | 1.003(0.998,1.007) | 0.263 | |||
| Weighted mode | 0.004 | 1.003(0.995,1.010) | 0.527 | |||
| Order | Actinomycetales | 5 | Inverse variance weighted | 0.003 | 1.007(1.000,1.013) | 0.047 |
| MR Egger | 0.009 | 1.011(0.993,1.030) | 0.320 | |||
| Simple mode | 0.005 | 1.007(0.997,1.018) | 0.255 | |||
| Weighted median | 0.004 | 1.007(1.000,1.015) | 0.047 | |||
| Weighted mode | 0.005 | 1.007(0.997,1.017) | 0.241 | |||
| Victivallales | 8 | Inverse variance weighted | 0.007 | 1.004(1.001,1.008) | 0.019 | |
| MR Egger | 0.002 | 1.009(0.996,1.022) | 0.227 | |||
| Simple mode | 0.007 | 1.002(0.995,1.010) | 0.563 | |||
| Weighted median | 0.004 | 1.003(0.998,1.007) | 0.265 | |||
| Weighted mode | 0.002 | 1.002(0.995,1.010) | 0.541 | |||
| Family | Actinomycetaceae | 5 | Inverse variance weighted | 0.003 | 1.007(1.000,1.013) | 0.046 |
| MR Egger | 0.009 | 1.011(0.993,1.030) | 0.319 | |||
| Simple mode | 0.005 | 1.007(0.996,1.018) | 0.262 | |||
| Weighted median | 0.004 | 1.007(1.000,1.014) | 0.046 | |||
| Weighted mode | 0.005 | 1.007(0.997,1.017) | 0.244 | |||
| Peptostreptococcaceae | 14 | Inverse variance weighted | 0.002 | 1.005(1.001,1.009) | 0.014 | |
| MR Egger | 0.005 | 1.009(0.992,1.010) | 0.865 | |||
| Simple mode | 0.005 | 1.009(0.100,1.019) | 0.079 | |||
| Weighted median | 0.003 | 1.006(0.100,1.012) | 0.065 | |||
| Weighted mode | 0.004 | 0.100(0.991,1.009) | 0.981 | |||
| Streptococcaceae | 14 | Inverse variance weighted | 0.003 | 0.993(0.988,0.999) | 0.013 | |
| MR Egger | 0.011 | 0.984(0.963,1.007) | 0.194 | |||
| Simple mode | 0.007 | 0.992(0.979,1.005) | 0.251 | |||
| Weighted median | 0.004 | 0.993(0.986,1.001) | 0.069 | |||
| Weighted mode | 0.007 | 0.993(0.980,1.007) | 0.330 | |||
| Genus | Eubacterium ventriosum group | 15 | Inverse variance weighted | 0.002 | 1.006(1.001,1.011) | 0.017 |
| MR Egger | 0.011 | 1.023(1.002,1.045) | 0.052 | |||
| Simple mode | 0.005 | 1.012(1.001,1.023) | 0.049 | |||
| Weighted median | 0.003 | 1.008(1.002,1.015) | 0.010 | |||
| Weighted mode | 0.005 | 1.011(1.000,1.022) | 0.060 | |||
| Ruminococcus gnavus group | 12 | Inverse variance weighted | 0.002 | 1.004(1.001,1.008) | 0.025 | |
| MR Egger | 0.009 | 1.009(0.991,1.027) | 0.332 | |||
| Simple mode | 0.004 | 1.007(0.100,1.015) | 0.084 | |||
| Weighted median | 0.002 | 1.006(1.002,1.011) | 0.008 | |||
| Weighted mode | 0.004 | 1.007(1.000,1.015) | 0.073 | |||
| Ruminiclostridium6 | 16 | Inverse variance weighted | 0.002 | 1.005(1.002,1.009) | 0.006 | |
| MR Egger | 0.005 | 0.999(0.990,1.009) | 0.860 | |||
| Simple mode | 0.006 | 1.012(1.001,1.024) | 0.050 | |||
| Weighted median | 0.003 | 1.005(0.999,1.010) | 0.084 | |||
| Weighted mode | 0.005 | 0.999(0.988,1.010) | 0.856 | |||
| Streptococcus | 15 | Inverse variance weighted | 0.003 | 0.993(0.986,0.997) | 0.003 | |
| MR Egger | 0.009 | 0.969(0.952,0.986) | 0.002 | |||
| Simple mode | 0.006 | 0.989(0.977,1.002) | 0.122 | |||
| Weighted median | 0.003 | 0.992(0.985,0.999) | 0.020 | |||
| Weighted mode | 0.006 | 0.990(0.978,1.001) | 0.095 |