Table 4.
Longitudinal associations of stress with immune and neuroendocrine profiles
| Adjustments | Stress | ||||
|---|---|---|---|---|---|
| RRR | SE | 95% CI | P | ||
| Moderate-risk Profile | |||||
| Model 1: Unadjusted | 1.26 | 0.12 | 1.05 | 1.50 | 0.012 |
| Model 2: Model 1 + baseline profiles a | 1.23 | 0.12 | 1.03 | 1.48 | 0.025 |
| Model 3: Model 2 + demographics & genetics b | 1.28 | 0.12 | 1.06 | 1.54 | 0.010 |
| Model 4: Fully Adjusted c | 1.18 | 0.12 | 0.97 | 1.43 | 0.093 |
| High-risk Profile | |||||
| Model 1: Unadjusted | 1.57 | 0.15 | 1.30 | 1.90 | <0.001 |
| Model 2: Model 1 + baseline profiles a | 1.52 | 0.17 | 1.21 | 1.90 | <0.001 |
| Model 3: Model 2 + demographics & genetics b | 1.65 | 0.19 | 1.31 | 2.07 | <0.001 |
| Model 4: Fully Adjusted c | 1.42 | 0.17 | 1.12 | 1.80 | 0.004 |
Notes: The low-risk group is the reference; RRR = relative risk ratio; SE = standard errors; CI = confidence interval; p = significance value.
Baseline immune and neuroendocrine profiles.
Demographic and genetic variables: age; sex; 10 principal components (PCs); C-reactive Protein (CRP) polygenic score (PGS); White Blood Cell Counts (WBCC) PGS; Insulin Growth Factor-1 (IGF-1) PGS; [Hair] Cortisol PGS; Sleep Duration PGS.
All variables: Baseline immune and neuroendocrine profiles; age; sex; 10 PCs; CRP PGS; WBCC PGS; IGF-1 PGS; Cortisol PGS; education; wealth; occupational social status; smoking status; alcohol consumption; physical activity; mobility; limiting longstanding illness; health (i.e., chronic lung disease; coronary heart disease; abnormal heart rhythm; heart murmur; congestive heart failure; angina; hypertension; diabetes; cancer; Parkinson’s; Alzheimer’s; dementia; asthma; arthritis; osteoporosis; psychiatric disorder).