Table 7.
Longitudinal associations of immune and neuroendocrine profiles with suboptimal sleep
| Adjustments | Moderate-risk Profile | ||||
|---|---|---|---|---|---|
| RRR | SE | 95% CI | P | ||
| Short Sleep | |||||
| Model 1: Unadjusted | 1.51 | 0.15 | 1.24 | 1.84 | <0.001 |
| Model 2: Model 1 + baseline profiles a | 1.38 | 0.15 | 1.11 | 1.71 | 0.003 |
| Model 3: Model 2 + demographics & genetics b | 1.38 | 0.15 | 1.11 | 1.72 | 0.004 |
| Model 4: Fully Adjusted c | 1.21 | 0.14 | 0.96 | 1.51 | 0.103 |
| Adjustments | High-risk Profile | ||||
| RRR | SE | 95% CI | P | ||
| Model 1: Unadjusted | 1.33 | 0.20 | 0.99 | 1.79 | 0.059 |
| Model 2: Model 1 + baseline profiles a | 1.13 | 0.19 | 0.82 | 1.57 | 0.454 |
| Model 3: Model 2 + demographics & genetics b | 1.11 | 0.19 | 0.80 | 1.54 | 0.539 |
| Model 4: Fully Adjusted c | 0.86 | 0.15 | 0.61 | 1.22 | 0.388 |
| Adjustments | Moderate-risk Profile | ||||
| RRR | SE | 95% CI | P | ||
| Long Sleep | |||||
| Model 1: Unadjusted | 2.14 | 0.31 | 1.61 | 2.83 | <0.001 |
| Model 2: Model 1 + baseline profiles a | 2.11 | 0.31 | 1.58 | 2.80 | <0.001 |
| Model 3: Model 2 + demographics & genetics b | 1.91 | 0.28 | 1.43 | 2.56 | <0.001 |
| Model 4: Fully Adjusted c | 1.66 | 0.25 | 1.23 | 2.23 | 0.001 |
| Adjustments | High-risk Profile | ||||
| RRR | SE | 95% CI | P | ||
| Model 1: Unadjusted | 2.93 | 0.53 | 2.06 | 4.18 | <0.001 |
| Model 2: Model 1 + baseline profiles a | 2.81 | 0.52 | 1.96 | 4.03 | <0.001 |
| Model 3: Model 2 + demographics & genetics b | 2.30 | 0.43 | 1.59 | 3.33 | <0.001 |
| Model 4: Fully Adjusted c | 1.81 | 0.35 | 1.24 | 2.64 | 0.002 |
Notes: The low-risk group is the reference; RRR = relative risk ratio; SE = standard errors; CI = confidence interval; p = significance value.
Baseline immune and neuroendocrine profiles.
Demographic and genetic variables: age; sex; 10 principal components (PCs); C-reactive Protein (CRP) polygenic score (PGS); White Blood Cell Counts (WBCC) PGS; Insulin Growth Factor-1 (IGF-1) PGS; [Hair] Cortisol PGS; Sleep Duration PGS.
All variables: Baseline immune and neuroendocrine profiles; age; sex; 10 PCs; CRP PGS; WBCC PGS; IGF-1 PGS; Cortisol PGS; education; wealth; occupational social status; smoking status; alcohol consumption; physical activity; mobility; limiting longstanding illness; health (i.e., chronic lung disease; coronary heart disease; abnormal heart rhythm; heart murmur; congestive heart failure; angina; hypertension; diabetes; cancer; Parkinson’s; Alzheimer’s; dementia; asthma; arthritis; osteoporosis; psychiatric disorder).