Table 3.

Assessment of methodological quality of preclinical studies.

Author, year	Sequence generation	Baseline characteristics	Allocation concealment	Random housing	Performance blinding	Random outcome assessment	Detection blinding	Incomplete outcome data	Selective outcome reporting	Other sources of bias
Alpan et al., 2022 [31]	+	?	–	?	–	–	+	+	+	+
Catanzaro et al., 2018 [32]	–	+	–	?	–	–	+	+	+	+
Cirano et al., 2021 [33]	–	+	–	?	–	–	+	+	+	+
Gennaro et al., 2015 [34]	–	–	–	?	–	–	?	–	+	+
Toker et al., 2018 [35]	–	?	–	?	–	–	+	+	+	–
Zhen et al., 2015 [36]	+	+	–	?	–	–	–	?	+	+

+: low risk; ?: unclear risk; –: high risk.