Table 2.
Comparison of primary and secondary outcomes of patients with prostate cancer on androgen deprivation therapy who were treated with or without SGLT2 inhibitors for type II diabetes mellitus.
| Outcomes | SGLT2 inhibitor (n=2,155) | No SGLT2 inhibitor (n=2,155) | ARD (95% CI) | Odd Ratio (95% CI) | p-value | E-value for OR | E-value for lower bound CI of OR |
|---|---|---|---|---|---|---|---|
| Composite of Outcomes (All-cause mortality/HF/AMI/PAD) | 218(16.1%) (n=1,351) |
355(26.3%) (n=1,349) |
−0.102 (−0.132,−0.071) |
0.539 (0.446, 0.651) (HR 0.689, 95% CI 0.5820.816; p<0.001) |
<0.001 | 2.47 | 2.88 |
| All-Cause Mortality | 168(7.8%) (n=2,155) |
365(16.9%) (n=2,155) |
−0.091 (−0.111,−0.072) |
0.415 (0.342,0.503) |
<0.001 | 4.31 | 5.33 |
| Heart Failure | 95(5.6%) (n=1,710) |
141(8.1%) (n=1,734) |
−0.026 (−0.043,−0.009) |
0.665 (0.508,0.870) |
0.003 | 2.4 | 3.33 |
| Acute Myocardial Infarction | 45(2.3%) (n=1,951) |
65(3.3%) (n=1,952) |
−0.010 (−0.021,0.000) |
0.685 (0.466,1.008) |
0.053 | 2.3 | 3.77 |
| Peripheral Artery Disease | 115(7.0%) (n=1,636) |
171(10.5%) (n=1,633) |
−0.034 (−0.054,−0.015) |
0.646 (0.505,0.828) |
<0.001 | 2.5 | 3.41 |
| Heart Failure Exacerbation | 243(11.3%) (n=2,155) |
288(13.4%) (n=2,155) |
−0.021 (−0.040,−0.001) |
0.824 (0.687,0.989) |
0.037 | 1.74 | 2.3 |
| Left Ventricular Ejection Fraction <50% | 12(0.57%) (n=2,083) |
24(1.1%) (n=2,096) |
−0.006 (−0.011,−0.000) |
0.503 (0.252,1.003) |
0.047 | 3.41 | 7.46 |
| Atrial Fibrillation/Flutter | 83(4.6%) (n=1,819) |
113(6.2%) (n=1,816) |
−0.017 (−0.031,−0.002) |
0.721 (0.539,0.964) |
0.027 | 2,12 | 3.18 |
| Cardiac Arrest | 18(0.83) (n=2,155) |
35(1.6%) (n=2,155) |
−0.008 (−0.014,−0.001) |
0.510 (0.288,0.904) |
0.019 | 3.33 | 6.6 |
| Ischemic Stroke | 40(1.98) (n=2,014) |
47(2.3) (n=2,004) |
−0.004 (−0.013,0.005) |
0.844 (0.551,1.292) |
0.434 | 1.67 | 3.04 |
| Renal Replacement Therapy | 11(0.5%) (n=2,155) |
45(2.1%) (n=2,155) |
−0.016 (−0.023,−0.009) |
0.241 (0.124,0.466) |
<0.001 | 7.8 | 16.15 |
| ER Visit/Hospitalization | 894(41.5%) (n=2,155) |
1,216(56.4%) (n=2,155) |
−0.149 (−0.179,−0.120) |
0.547 (0.485,0.618) |
<0.001 | 3.11 | 3.59 |
Abbreviations: SGLT2 – Sodium–glucose transport protein 2; ARD – Absolute risk difference; HF – heart failure; AMI – acute myocardial infarction; PAD – peripheral artery disease; ER – emergency room