Skip to main content
. 2024 Jul 24;11:1429180. doi: 10.3389/fmolb.2024.1429180

FIGURE 2.

FIGURE 2

Cryo-ET and single particle cryo-EM of HIV-1 Env. (A) From left to right, CD4-binding site antibody VRC01 and CD4-induced antibody 17b (EMD-5461), CD4-binding site antibody b12 (EMD-5018), sCD4 and CD4-induced antibody m36 (EMD-5554), and V3-glycan antibody 10-1074 and CD4-binding site antibody 3BNC117 (EMD-21413). (B) Cryo-ET study of HIV-1 entry mechanism. From left to right, One (EMD-29292), two (EMD-29293) and three (EMD-29294) CD4 molecules sequentially bound to native HIV-1 Env on membrane brings the host and viral membranes close to each other to initiate the fusion process. (C) Single particle cryo-EM of HIV-1 Env conformational states. From left to right, closed (EMD-8714), open-occluded (EMD-25878, bound antibody not shown), open (EMD-8713, bound CD4 and antibody not shown) conformational states are shown with the Env colored sea green, V1V2 loop colored orange, V3 loop colored pink and CD4 binding site colored medium orchid. Each panel includes a schematic representation.